Vlog #15 20 years of depression resolved.

Vlog #15 I had mild/moderate depression for over 20 years. I tried many (non-drug) treatments but was unable to make any impact on it beyond managing the symptoms. Three years ago I made some dramatic changes to my diet for completely different reasons. An unexpected event that followed four weeks afterwards was that my depression completely resolved and has not returned. I will never know if the change caused the resolution. But as I discuss in this post, with reference to the evidence, it is at least plausible that it may have been causative. Nothing in this post is advice. I just want to share what I did. I should also urge anyone considering changes to their treatment regime for mental health issues, pharmacological or otherwise, to do so in consultation with their doctor.

The scientific references that accompany this post can be found below. I encourage interested viewers to read them in full rather than take them at face value.


1. LaChance, L. R. and D. Ramsey (2018). "Antidepressant foods: An evidence-based nutrient profiling system for depression." World journal of psychiatry 8(3): 97-104. https://www.ncbi.nlm.nih.gov/pubmed/30254980

2. Mattson, M. P., K. Moehl, N. Ghena, M. Schmaedick and A. Cheng (2018). "Intermittent metabolic switching, neuroplasticity and brain health." Nat Rev Neurosci 19(2): 63-80. https://www.ncbi.nlm.nih.gov/pubmed/29321682

3. Brietzke, E., R. B. Mansur, M. Subramaniapillai, V. Balanza-Martinez, M. Vinberg, A. Gonzalez-Pinto, J. D. Rosenblat, R. Ho and R. S. McIntyre (2018). "Ketogenic diet as a metabolic therapy for mood disorders: Evidence and developments." Neurosci Biobehav Rev 94: 11-16. https://www.ncbi.nlm.nih.gov/pubmed/30075165

4. Pinto, A., A. Bonucci, E. Maggi, M. Corsi and R. Businaro (2018). "Anti-Oxidant and Anti-Inflammatory Activity of Ketogenic Diet: New Perspectives for Neuroprotection in Alzheimer's Disease." Antioxidants (Basel) 7(5). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981249/

5. Gao, Y., M. Bielohuby, T. Fleming, G. F. Grabner, E. Foppen, W. Bernhard, M. Guzman-Ruiz, C. Layritz, B. Legutko, E. Zinser, C. Garcia-Caceres, R. M. Buijs, S. C. Woods, A. Kalsbeek, R. J. Seeley, P. P. Nawroth, M. Bidlingmaier, M. H. Tschop and C. X. Yi (2017). "Dietary sugars, not lipids, drive hypothalamic inflammation." Mol Metab 6(8): 897-908. https://www.ncbi.nlm.nih.gov/pubmed/28752053

6. Akhtar, S., A. Ahmed, M. A. Randhawa, S. Atukorala, N. Arlappa, T. Ismail and Z. Ali (2013). "Prevalence of vitamin A deficiency in South Asia: causes, outcomes, and possible remedies." Journal of health, population, and nutrition 31(4): 413-423. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905635/ 

7. Spiteller, G. and M. Afzal (2014). "The action of peroxyl radicals, powerful deleterious reagents, explains why neither cholesterol nor saturated fatty acids cause atherogenesis and age-related diseases." Chemistry 20(46): 14928-14945. https://www.ncbi.nlm.nih.gov/pubmed/25318456

8. Pepe, S., N. Tsuchiya, E. G. Lakatta and R. G. Hansford (1999). "PUFA and aging modulate cardiac mitochondrial membrane lipid composition and Ca2+ activation of PDH." Am J Physiol 276(1): H149-158. https://www.ncbi.nlm.nih.gov/pubmed/9887028

9. Treadway, M. T., J. A. Cooper and A. H. Miller (2019). “Can't or Won’t? Immunometabolic Constraints on Dopaminergic Drive." Trends in Cognitive Sciences 23(5): 435-448. https://www.ncbi.nlm.nih.gov/pubmed/30948204

10. Gerster, H. (1998). "Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)?" Int J Vitam Nutr Res 68(3): 159-173. https://www.ncbi.nlm.nih.gov/pubmed/9637947

11. Hibbeln, J. R., K. Northstone, J. Evans and J. Golding (2018). "Vegetarian diets and depressive symptoms among men." J Affect Disord 225: 13-17. https://www.ncbi.nlm.nih.gov/pubmed/28777971 

Further notes

In the video I discuss differences in plant/animal forms of vitamins and their precursors. This relates to the concept of bioavailability. For a discussion on this, see this paper:

Gregory, J. F., 3rd (2012). "Accounting for differences in the bioactivity and bioavailability of vitamers." Food & nutrition research 56: https://www.ncbi.nlm.nih.gov/pubmed/22489223